产品货号：
Z37730
中文名称：
Factor XIIIa/F13A1抗体
英文名称：
Anti-Factor XIIIa/F13A1 Antibody (Clone#OTI3F6)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Factor XIIIa/F13A1 Antibody (Clone#OTI3F6) |
| 指标别名 | Coagulation factor XIIIa;F13A;F13A1;Transglutaminase A chain |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | F13A1 |
| 克隆号 | OTI3F6 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Full length human recombinant protein of human F13A1 (NP_000120) produced in HEK293T cell. |
| 实际分子量 | 79.2KD |
| 成分 | PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | This gene encodes the coagulation factor XIII A subunit.Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade.Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits.The A subunits have catalytic function,and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules.Platelet factor XIII is comprised only of 2 A subunits,which are identical to those of plasma origin.Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion,the plasma factor XIII dissociates its B subunits and yields the same active enzyme,factor XIIIa,as platelet factor XIII.This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules,thus stabilizing the fibrin clot.It also crosslinks alpha-2-plasmin inhibitor,or fibronectin,to the alpha chains of fibrin.Factor XIII deficiency is classified into two categories:type I deficiency,characterized by the lack of both the A and B subunits;and type II deficiency,characterized by the lack of the A subunit alone.These defects can result in a lifelong bleeding tendency,defective wound healing,and habitual abortion.[provided by RefSeq,Jul 2008] |
| Uniprot ID | P00488 |
| 基因名全称 | coagulation factor XIII A chain |
| 蛋白名全称 | Coagulation factor XIII A chain |
| 推荐稀释比 | Western blot (WB) 1:2000 Immunohistochemistry in paraffin section (IHC) 1:150 |
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